In NASH, there is also an increase in pro-inflammatory markers, such as C-reactive protein (CRP), IL-6, TNF-α, as well as pro-coagulant factors (fibrinogen, factor VIII, and plasminogen activator inhibitor-1), pro-oxidant molecules (oxidized LDL-cholesterol, thiobarbituric acid-reacting substances, and nitrotyrosine), and pro-fibrogenic mediators such as transforming growth factor beta-1 (TGF-β1), IGF-1, and endothelin-1 [71]. This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.