SREBF2 and metabolic dysfunction-associated steatohepatitis: In line with this, both sterol regulatory element-binding protein 2 (SREBP-2) and 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) are increased in NASH patients; sterol regulatory element-binding protein 2 (SREBP-2) is a transcriptional regulator of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA), which is a rate-limiting enzyme in de novo cholesterol synthesis [69,70].