ACE2 and viral infectious disease: In the placenta, a 7-plex mIHC panel confirmed the epithelial cytokeratin+ syncytiotrophoblasts as the main target for viral infection by virtue of expression of ACE2 and the presence of dsRNA in a well-defined dotted pattern (Figure 2B and Figure S2A), a pattern of distribution which was essentially preserved with antibodies against the Coronaviridae family or SARS-CoV-2-specific antigens (Figure S2B).