NFE2L2 and metabolic dysfunction-associated steatohepatitis: By feeding Wild-type or nuclear erythroid 2-related factor 2 (Nrf2) knock-out mice with the choline-deficient, l-amino acid-defined, high-fat diet, researchers found that aloin supplementation possesses antioxidant, anti-inflammatory, and anti-apoptotic activity effects on non-alcoholic steatohepatitis mice by activating the Nrf2/HO-1 pathway [18].