SOD1 and amyotrophic lateral sclerosis: In the SOD1 activity, this disproportion was even more pronounced since the ALS mice SOD1 activity was 6.3-fold higher than in the WT group (p < 0.005) (Figure 3B); whereas the SOD2 activity in the ALS before group was 4.5 times higher than in the WT group (p < 0.005) (Figure 3C).