CD63 and Zika virus infectious disease: Since tetraspanins (CD9, CD63, and CD81) were shown to be critical in endosomal sorting complex required for transport (ESCRT)-dependent and -independent EV biogenesis, enhanced EV biogenesis was observed with a concomitant rise in CD63 levels 48 h post ZIKV infection in SNB-19 cells (human glioblastoma cells) [101].