At the same time, AD modeling by injection of beta-amyloid did not cause significant changes in lactate in NLRP3 knockout mice (23.375 ± 5.34 nmol/μg protein) and in wild-type mice (22.37 ± 8.78 nmol/μg protein) (p > 0.9999, Sidak’s correction). This evidence concerns the gene NLRP3 and Alzheimer disease.