NLRP3 and early-onset autosomal dominant Alzheimer disease: Thus, in NLRP3KO knockout mice, when modeling Alzheimer’s disease by Aβ injection, an overlap coefficient of 0.42 ± 0.18 was revealed, compared with that in the NLRP3 KO + PBS group of 0.36 ± 0.1 (p > 0.05, Sidak’s correction).