ACHE and Neurodevelopmental delay: In the particular case of NDD, the multifunctionality of the desired therapeutic one-molecule multiple-target chemicals should include some of the following effects: (i) inhibition of acetylcholinesterase (AChE); (ii) inhibition of monoamine oxidase (MAO); (iii) inhibition of catechol O-methyltransferase (COMT); (iv) antioxidant behavior; (v) free radical scavenging activity; and (vi) metal chelating power [1,21,22,23,24,25,26,27,28,29,30,31,32,33,34].