Another study by Chen et al. [73] reported that essential oil from A. adenophora promoted HCC (hepatocellular carcinoma) apoptosis by activating the mitochondria and endoplasmic reticulum apoptotic signaling pathways as well as inhibiting the action of STAT3 (signal transducer and activator of transcription 3) and AKT (protein kinase B). This evidence concerns the gene STAT3 and hepatocellular carcinoma.