After extensive analysis of various parameters in chronically CCl4-treated LysM-Crepos x Smad7Δ/Δ mice and their LysM-Creneg Smad7fl/fl littermate controls, our results indicated that liver fibrosis development did not depend on the presence of Smad7 in LysM-expressing cells. This evidence concerns the gene SMAD7 and Hepatic fibrosis.