Within the hematopoietic system, POT1 shows the highest expression levels in hematopoietic stem and progenitor cells, as visualised by single-cell RNA sequencing data from the Human Cell Atlas (Figure 5A), while Western blot analyses show varying levels of POT1 in the ALL and AML cell lines (Supplementary Figure S4A). Here, POT1 is linked to acute myeloid leukemia.