Supported by the literature, the enrichment of HIV-1 infection [18,19] and hepatitis B infection [20] associated pathways, NF-κβ [21,22], VEGF [23] and toll-like receptor signalling [24] pathways, diminishment of peroxisome [25,26] and morphine addiction [27] associated pathways in CBE was found among interesting AD-associated abnormalities. This evidence concerns the gene VEGFA and Alzheimer disease.