CEP290 and Leber congenital amaurosis: BRILLIANCE (NCT03872479) is a Phase 1/2 study sponsored by Editas Medicine (Cambridge, MA, USA) using CRISPR-Cas9 gene editing to treat the most common disease-causing variant responsible for LCA, CEP290 c.2991 + 1655A > G (IVS26) [172] (Table 1).