MAPK3 and neoplasm: The authors also found an inverse relationship between phospho-ERK1/2 activity and DUSP9 expression in TNBC xenografts, as well as in TNBC mammospheres [35], However, in contradiction with the previous study, they showed that the pharmacological or genetic depletion of DUSP9 reduced the growth of TNBC mammospheres in vitro, as well as tumor growth and mass in vivo [35],