Similarly, the presence of chromosomal translocations such as EWSR1-NR4A3, RBP56-NR4A3 and TCF12-NR4A3 in myxoid chondrosarcomas [67] as well as HEY1-NCOA2 and IRF2BP2-CDX1 in mesenchymal chondrosarcoma [68] are well identified in CS. This evidence concerns the gene NR4A3 and Cowden syndrome 1.