MTOR and neuroblastoma: MitoTEMPO has neuroprotective effects against glutamate cytotoxicity through its direct free radical-scavenging activity and suppresses autophagic flux via the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) signaling pathway in neuroblastoma SH-SY5Y cells [222].