Changes in the expression of the cytochrome P450 family proteins, in particular Cyp2e1, Cyp1a1, Cyp4a1, and Cyp4a2, which are involved in the pathogenesis of NAFLD, had a beneficial effect on lipid metabolism and insulin signaling after empagliflozin administration. The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatotic liver disease.