Amplification of the gene encoding the epidermal growth factor receptor (EGFR) is commonly observed in GBM, leading to the activation of further kinases, including phosphatidylinositol 3′-kinase (PI3K), protein kinase B (AKT), and the mammalian target of rapamycin (mTOR). The gene discussed is AKT1; the disease is glioblastoma.