The orthologs of the genes on commercial human PCa multi-gene assays are associated with cell cycle progression (CDK1, BUB1B, ORC6, RAD51, PLK1, PTTG1 and RRM2), cell proliferation (IQGAP3), stromal response (COL1A1), cell adhesion (THBS2), stress response (FOS), and androgen signaling (KLK2, SRD5A2). Here, RRM2 is linked to posterior cortical atrophy.