KLK2 and Familial prostate cancer: The “prostate cancer” pathway also comprises genes that are relatively specific to the (human) prostate (CREB3L4, KLK2, NKX3-1 and SRD5A2), proto-oncogenes (EGFR, NRAS, PDGFRA and PDGFRB), and druggable candidates (CDKN1A, CTNNB1, EGFR, NRAS, PDGFRA, PDGFRB, PIK3CD and PIK3CG) (Figure 4B, Table S1).