In vitro and in vivo, the interaction of TRAILs, such as TRAILR1 (also known as DR4) and TRAILR2 (also known as DR5), with death receptors (DRs) on the surface of cancer cells can cause apoptotic cell death signaling via the death-receptor-mediated apoptosis pathway, with little effect on normal cells [38]. This evidence concerns the gene TNFRSF10B and cancer.