PDK3 and neoplasm: Interestingly, GEO analysis of the dataset (GSE30784) [28] of OSCC samples (tumor = 167 and normal = 45), using GEO2R online tool [29], the volcano plot showing differentially expressed genes (Supplementary Figure S1A) in the OSCC samples compared to normal (p < 0.05), the expression of the glycolytic gene (LDHA, PDK3 and PFKP) were up-regulated in the OSCC samples.