For certain genes (Il10, Csf3, Cxcl1, Ccl2, Gata3, Il5, and Il13), there was a clear difference between the EC and HC Shb KO effects using Cdh5-CreERt2 or Vav1-Cre tumor-bearing mice, indicating that these effects reflect EC cell autonomy of Shb gene deletion. The gene discussed is VAV1; the disease is neoplasm.