rhACE2 could bind to the spike protein by competing with ACE2 on the cell membrane surface, which on the one hand, inhibited the virus from infecting cells, on the other hand, rhACE2 could activate ACE2-Ang (1-7)-MasR pathway, reducing lung inflammation, and alleviating lung injury or ARDS. The gene discussed is ANGPT1; the disease is acute respiratory distress syndrome.