The chronic wounds are characterized by prolonged inflammation and healing, elevated levels of matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), reduced level of pro-healing growth factors (e.g., transforming growth factor-beta 1—TGF-β1, vascular endothelial growth factor–VEGF), senescent cell populations, lack of microvasculature, and susceptibility to infections [2,3]. The gene discussed is VEGFA; the disease is infection.