To determine whether the purinergic receptors, Pannexin-1 and ectonucleotidase coding genes might differentially be expressed in CRC cells compared to normal-like colonic cells, we included here mRNA samples prepared from the non-tumorigenic and undifferentiated immortalized epithelial progenitor HCEC-1CT cells [55]. This evidence concerns the gene P2RX4 and colorectal carcinoma.