To further characterize the cell death processes induced by extracellular ATP, CRC cells were treated for 48 h with 250 μM ATP given in the absence or presence of QVD-Oph (a pan-caspase inhibitor with potent anti-apoptotic properties) or Necrostatin-1 (an RIPK1 inhibitor with potent anti-necroptosis activities) (Figure 4D). Here, RIPK1 is linked to colorectal carcinoma.