Indeed, while our data clearly demonstrated that P2RY2 plays a unique role in Ca2+ mobilization when CRC cells were exposed to extracellular ATP (Figure 6A), its selective pharmacological inhibition either had no effect (HCT116, LS174T, LS513) or reversed (HT29) the effects of ATP on CRC cell survival (Figure 6B). This evidence concerns the gene P2RY2 and colorectal carcinoma.