However, because Ca2+ mobilization as well as extracellular ATP exposure and P2RY2 activation have been involved in metastasis, cell cycle progression, cell motility and drug resistance [2,28,40,41,42,73,74,76,77,78,79,80,81,82], it would be interesting to further explore the effects of P2RY2 inhibition on these specific cellular processes associated with cancer progression. This evidence concerns the gene P2RY2 and cancer.