In a phase 1/2 multicenter trial (NCT01994850), 29 patients with ND CD30+ B-cell lymphomas (22 PMBCL, 5 DLBCL, 2 GZL) were treated with 6 cycles of BV + R-CHP and 52% of patients followed consolidative radiotherapy [19]. The gene discussed is TNFRSF8; the disease is diffuse large B-cell lymphoma.