MMP2 and breast carcinoma: The antitumor cellular effects of BBR related to breast cancer mainly include (1) inducing apoptosis of MCF-7 by promoting ROS formation, overexpressing TP53 and WAF1/p21, and down-regulating BCL2; (2) inhibiting the metastasis of MDA-MB-231 cells by down-regulating PI3K/AKT, NF-κB, AP-1, and matrix metallopeptidase MMP2/9; (3) affecting the autophagy and growth of breast cancer cells by up-regulating beclin-1, down-regulating BCL2, and inhibiting mTOR [10,11,12,13].