KDM6B and Merkel cell skin cancer: In particular, hypomethylation at Lysine Demethylase 6B (KDM6B), a gene involved in the negative regulation of H3K27me3 [150,151], has been hypothesized to prompt KDM6B overexpression in MCPyV-driven MCC, ultimately leading to a global reduction of H3K27me3 [121].