Accordingly, cGAS-/- mice exhibited less severe sepsis than the wildtype (WT) mice, as indicated by survival analysis, endotoxemia at 24 h (but not at 6 h post CLP) and serum cell-free DNA (cfDNA) at 6 h (but not at 24 h post CLP) (Figure 1A–C). Here, CGAS is linked to serum lipopolysaccharide activity.