Due to sepsis increasing serum cfDNAs and mtDNAs [40], which promote inflammation through cGAS activation [14,15,41], and with injection of bacterial DNA with LPS worsening sepsis severity [28], the fact that blockage of cGAS downstream-signaling, STING and Interferon regulatory factor 3 (IRF3) attenuates sepsis [23] suggests that the exploration of sepsis in cGAS-/- mice and macrophages would be worthwhile, especially considering the limitedness of research into sepsis in cGAS deficient (cGAS-/-) mice. This evidence concerns the gene IRF3 and Sepsis.