NKX2-4 and acute myeloid leukemia: Taken together, our experimental data for NKX2-4 in acute erythroblastic leukemia cell line OCI-M2 correspond to expression data from AML-M6 patients and primary MEPs, suggesting that this aberrantly activated NKL homeobox gene may provoke a developmental defect in the process of megakaryocyte–erythroid differentiation.