However, a potential role for overexpressed histone genes in aberrant NKX2-4 expression remained unclear, although we additionally detected elevated levels of ubiquitinated H2B in OCI-M2 (Figure 3D), which has been shown to impact NKL homeobox gene activity in B-cell lymphoma [28]. The gene discussed is H2BC21; the disease is B-cell non-Hodgkin lymphoma.