More specifically, tumor cells adhere to stromal cells, activate several antiapoptotic pathways such as Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) and upregulate anti-apoptotic proteins such as BcL-xL, nuclear factor-κB (NF-κB) and Mcl-1 [86]. The gene discussed is STAT3; the disease is neoplasm.