Here, we found that PSPAs treatment could increase Nrf2 expression and nuclear translocation (Figure 6A,B), and knock-down of Nrf2 aggravates KP-mediated mitochondrial dysfunction (Figure 6G,H) by impeding PINK1 accumulation and Parkin recruitment on the mitochondrial membrane (Figure 6D,E) in response to PSPAs treatment, suggesting that Nrf2 plays a critical role in PSPAs in promoting mitophagy in KP-infected AMs cells. The gene discussed is PRKN; the disease is keratosis pilaris.