As in the case of Alport syndrome associated with the contiguous deletion of the COL4A5 and COL4A6 genes [67], excluding the association of the COL4A6 gene with said syn-drome [68], it would be interesting to identify the clinical or molecular relevance of the inactivation of the CLCNKA gene alone in BS. This evidence concerns the gene COL4A6 and Bloom syndrome.