SLC12A3 and Bartter syndrome: It is essential to bear in mind that ERAD, lysosomal degradation and the specific ubiquitination of unfolded and immature NCC and NKCC2 have also been widely described as key mechanisms of protein expression and localization [72,73,74,75], for which further study of Bartter’s disease type 5 will contribute to a greater understanding of these fundamental processes.