FN1 and obesity due to melanocortin 4 receptor deficiency: Parallelly, the presence of FN-fibrin complexes was also speculated for women who have problems with spontaneous conception, since low-grade chronic inflammation is associated with hypothyroidism [66], insulin resistance [67], obesity [68] and polycystic ovary syndrome [69], observed in 50.0%, 32.1%, 28.6% and 10.7%, respectively, of women with fertility disorders.