SLC39A8 and cancer: We analyzed the mRNA expression of ZIP8 in 40 types of cancers, and found that for those that showed significant differences in their ZIP8 expressions between tumor and healthy tissues, almost all were up-regulated and only five cancer types (acute myeloid leukemia, kidney renal clear cell carcinoma, liver hepatocellular carcinoma, thymoma, and uveal melanoma) contained a small percentage of tumor samples with down-regulated ZIP8 expression (Figure 6).