SLC39A8 and Leigh syndrome: 1171G>A) [21,23,36], and cells with ZIP8 containing these mutations appear to have dysregulated ion homeostasis (especially Mn) which can lead to diseases such as type II congenital disorder of glycosylation [37], Leigh syndrome [37], cardiovascular diseases [38], severe idiopathic scoliosis [39], and schizophrenia [40].