CASP1 and pneumococcal infection: IFN-I dependent NLRP6 inflammasome activation also induces the activation of caspase 11 along with caspase 1 activation via ASC for boisterous IL18 processing and enhanced pyroptosis mediated by caspase 1 and GSDMD [168,169] in Listeria and Streptococcus Pneumoniae infections.