BDNF and injury: In concordance with our data showing better therapeutic efficacy of BDNF-eMSCs than naïve MSCs transplantation against severe neonatal HI brain injury, Kurozumi et al. [24] reported that, along with a 23-fold increase in BDNF production, intracerebral transplantation of BDNF gene-transfected MSCs one day after induction of MCAO promoted functional recovery and reduced infarct size in rats.