Although the differences between CeD (n = 6) and controls (n = 5) did not reach significance for any of these cell types, immune cells did show a higher enrichment in CeD biopsies (B-cells: p = 0.03; CD8+ T-cells p = 0.076; immune cell score p = 0.094), and epithelial cells were significantly depleted in CeD compared to controls (p = 0.03) (Figure 5A). The gene discussed is CD8A; the disease is cranioectodermal dysplasia.