Transcriptomic analysis of intratumoral NK cells from NSCLC biopsies has revealed significantly reduced expression of sphingosine-1-phosphate receptor 1 (S1PR1) and CX3C chemokine receptor 1 (CX3CR1)—important receptors participating in the migration of NK cells into the tumor [95]. This evidence concerns the gene S1PR1 and non-small cell lung carcinoma.