IFNB1 and Autoimmunity: Another UR encodes immunity-related GTPase family M protein 1 (Irgm1), which modulates resistance to pathogens [46,47] and can contribute to autoimmunity [48,49]; similarly, the UR interferon beta 1 (IFNB1) is crucial for the antiviral immune response but can also contribute to autoimmunity (reviewed in [50,51]).