IFIH1 and viral infectious disease: Other targets contributing to the antiviral response included interferon gamma inducible protein 16 (IFI16), which mediates interferon beta production in response to viral infection [54], and interferon induced with helicase C domain 1 (IFIH1), which senses viral RNA to provoke an antiviral immune response and occasionally contributes to autoimmune diseases (for example, [55]).