Captopril also reduces the production of both subtypes of IL-12 (p40 and p70) by human peripheral blood mononuclear cells (PBMC) [42] and down-regulates the immune cells infiltrating arterial atherosclerotic lesions by down-regulating the C-C chemokine receptor 9 (CCR9) induced in atherosclerosis-prone apolipoprotein E (ApoE) deficient mice [50]. The gene discussed is APOE; the disease is atherosclerosis.