Colorectal cancer cells secrete 12(S)-HETE, which promotes CAF retraction from colorectal cancer spheroids by activating myosin light chain 2 (MLC2) through Ca2+/RHO/ROCK signaling axis, facilitating colorectal cancer cell migration into the stroma and surrounding regions (Figure 2C) [7]. The gene discussed is MYL2; the disease is colorectal cancer.