CASP8 and hepatocellular carcinoma: Recently Cheung KF et al., demonstrated that PPARγ overexpression in hepatoma cells showed significant inhibition of cell growth, increased cell apoptosis through intrinsic (caspase-3-p17, 7, 9 and PARP) and extrinsic (Fas, TNF-α, and caspase-8) pathways [43].