PFD has shown changes in cytokines and growth factors expression, such as TGF-b1, PDGF, INF-y, TNF-a, IL-1b, IL-6, IL8 in the lungs; TGF-b1 and MMP9 in the heart; mRNA of TGF-b1 in the kidney; and TGF-b1, MMP2 and TMP-1 in the liver in several animal models [17]. Here, TGFB1 is linked to polyostotic fibrous dysplasia.