We have, for the first time, identified an association between IDD and the CA HIF-1α, especially pHIF-1α Mut B. Sutter et al. demonstrated that missense mutations increase HIF-1α expression under normoxic conditions by blocking ubiquitination and missense mutations and/or deletions involving several different regions of HIF-1α, resulting in constitutive activation and transcriptional activity in normoxic cells. This evidence concerns the gene HIF1A and intervertebral disk degenerative disorder.