PIK3CA and neoplasm: Next-generation sequencing revealed recurrent somatic mutations in the neurofibromatosis 2 (NF2), TNF receptor associated factor 7 (TRAF7), Krüppel-like factor 4 (KLF4), AKT serine/threonine kinase 1 (AKT1), smoothened (SMO), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) genes, which are collectively found in around 80% of sporadic MGMs and are associated with tumor location, histologic subtype, and clinical outcome [6,7,10,16,17,18].