On the contrary, Michiels et al., described a platelet-mediated microvascular thrombotic syndrome, documenting thrombotic processes by a reduced platelet survival and by an increase in beta-thromboglobulin, platelet factor 4, and thrombomodulin levels in Polycythemia Vera (PV) and Essential Thrombocythemia (ET) patients [6]. This evidence concerns the gene PF4 and essential thrombocythemia.