INS and nicotine dependence: On the other hand, subcellular analysis revealed that DLB induces significant proteomic changes at the level of excitatory synapse, transmembrane transporter complexes and cytosolic small ribosomal subunits (Figure 4), converging in specific pathways such as neuropathic protein trafficking, Rag geranylgeranylation, transport of inorganic cations/anions, nicotine addiction and insulin secretion (Figure 5D and Figure 6A,C).