For that, an integrative analysis was performed using OB proteomics datasets derived from subjects with Alzheimer ́s disease (AD), Parkinson ́s disease (PD), mixed dementia (mixD), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD-TDP43), progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) with respect to OB proteome data from neurologically intact controls. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.