GNRH1 and endometriosis: Although there are still areas that require further scrutiny in terms of efficacy and safety in real-world populations, potential use of ABT, and comparisons with OCPs and progestins [107], we agree with Leyland et al. [108] that clinical evidence clearly demonstrates that oral GnRH antagonists are effective and well tolerated in patients with moderate-to-severe endometriosis-associated pain.