LLGL1 and neoplasm: Remarkably, Drosophila genes originally identified as tumor suppressor genes, such as discs large1 (dlg1)/DLG1, lethal (2) giant larvae (l(2)gl)/LLGL1, and brain tumor (brat)/TRIM3 were shown a posteriori to be key regulators of ACD [38,39,40], further supporting the link between failures in ACD and tumorigenesis.