In this regard, malvidin (Figure 5B) upregulated p21 expression levels in human colorectal cancer [71] and its combined use with blueberry induced cell death through Bax-mediated intrinsic pathway in SCC131 cells by inhibiting Bcl-2 with an increase in Bax expression and initiating cleavage of caspases [72]. Here, BAX is linked to colorectal cancer.