Bilberry extract (Figure 5B) (which contain delphinidin-3-O-glucoside, cyanidin-3-O-glucoside, delphinidin-3-O-rutinoside, cyanidin-3-O-galactoside, and cyanidin-3-O-rutinoside flavonoids) was applied to chronic lymphocytic leukemia which activated caspase-3, de-phosphorylated Akt and inhibited Bcl-2 and resulted in the induction of apoptosis [108]. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.