IRF3 and mesothelioma: IRF3 expression and the immune checkpoint genes significantly correlated with LAG3 and LGALS1 (Galectin) genes expression in mesothelioma cells, while positive correlation was found between IRF3 and HAVCR2 (TIM-3) or PDCD1LG2 (PD-L2) expression in monocytes/macrophages (Figure 6B).