High expression of IRF3 was associated with poor prognosis in colorectal carcinoma, kidney renal clear cell carcinoma, and prostate adenocarcinoma, but with good prognosis in pancreatic adenocarcinoma, suggesting that the cGAS/STING signaling pathway plays an organ-specific role in tumor progression. The gene discussed is IRF3; the disease is pancreatic adenocarcinoma.